2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Related Products

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Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands. Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, eg gemcitabine and 5-FU. Antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.

Nucleoside Antimetabolite/Analog Related Products (1902):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-138594
    5'-O-TBDMS-N2-ibu-dG
    5'-O-TBDMS-N2-ibu-dG is a nucleoside derivative and can be used for lead compounds synthesis with anti-bovine viral diarrhea virus activity.
    5'-O-TBDMS-N2-ibu-dG
  • HY-154599
    5-Me-3’-dU-2’-phosphoramidite
    5-Me-3’-dU-2’-phosphoramidite is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    5-Me-3’-dU-2’-phosphoramidite
  • HY-152582
    7-(3-Deoxy-β-D-erythro-pentofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
    7-(3-Deoxy-β-D-erythro-pentofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    7-(3-Deoxy-β-D-erythro-pentofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
  • HY-152528
    4’-C-Methyl-5-methylcytidine
    4’-C-Methyl-5-methylcytidine is a cytidine nucleoside analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities.
    4’-C-Methyl-5-methylcytidine
  • HY-152449
    3’-Beta-C-ethynyl-N6-(m-trifluoromethyl benzyl)adenosine
    3’-Beta-C-ethynyl-N6-(m-trifluoromethyl benzyl)adenosine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277). 3’-Beta-C-ethynyl-N6-(m-trifluoromethyl benzyl)adenosine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    3’-Beta-C-ethynyl-N6-(m-trifluoromethyl benzyl)adenosine
  • HY-152389
    6-Methylpurine-β-D-(3-azido-3-deoxy)riboside
    6-Methylpurine-β-D-(3-azido-3-deoxy)riboside is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc. 6-Methylpurine-β-D-(3-azido-3-deoxy)riboside is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    6-Methylpurine-β-D-(3-azido-3-deoxy)riboside
  • HY-154151
    N4-(3,3,3-Trifluoropropanoyl)cytidine
    N4-(3,3,3-Trifluoropropanoyl)cytidine is a cytidine analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities.
    N4-(3,3,3-Trifluoropropanoyl)cytidine
  • HY-154331
    1-(5-O-Methoxytrityl-2-deoxy-β-D-xylofuranosyl)uracil
    1-(5-O-Methoxytrityl-2-deoxy-β-D-xylofuranosyl)uracil is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    1-(5-O-Methoxytrityl-2-deoxy-β-D-xylofuranosyl)uracil
  • HY-154620
    2′-O-Hexadecyl-adenosine
    2′-O-Hexadecyl-adenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    2′-O-Hexadecyl-adenosine
  • HY-154333
    2′-Deoxy-8-(phenylmethoxy)guanosine
    2′-Deoxy-8-(phenylmethoxy)guanosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    2′-Deoxy-8-(phenylmethoxy)guanosine
  • HY-154468
    6-O-Methyl-2’-O-methylinosine
    6-O-Methyl-2’-O-methylinosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    6-O-Methyl-2’-O-methylinosine
  • HY-152570
    N6-Methyl-2’-O-(2-methoxyethyl) adenosine
    N6-Methyl-2’-O-(2-methoxyethyl) adenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    N6-Methyl-2’-O-(2-methoxyethyl) adenosine
  • HY-152877
    Isocytidine
    2-Amino-1-β-D-ribofuranosyl-4(1H)-pyrimidinone is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    Isocytidine
  • HY-152400
    8-Bromo-9-(β-D-xylofuranosyl) guanine
    8-Bromo-9-(β-D-xylofuranosyl) guanine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    8-Bromo-9-(β-D-xylofuranosyl) guanine
  • HY-W560803
    5'-DMTr-2,2'-anhydrothymidine
    5'-DMTr-2,2'-anhydrothymidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    5'-DMTr-2,2'-anhydrothymidine
  • HY-111647S1
    N2-Methylguanosine-d3
    N2-Methylguanosine-d3 is deuterium labeled N2-Methylguanosine (HY-111647). N2-Methylguanosine is a commonly modified nucleoside in rRNA and tRNA, with specific distributions in both E. coli rRNA and eukaryotic tRNA. N2-Methylguanosine can be found in urine. N2-Methylguanosine affects the structure and stability of RNA.
    N2-Methylguanosine-d<sub>3</sub>
  • HY-154343
    3′-Azido-3′-deoxy-5′-O-(triphenylmethyl)thymidine
    3′-Azido-3′-deoxy-5′-O-(triphenylmethyl)thymidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    3′-Azido-3′-deoxy-5′-O-(triphenylmethyl)thymidine
  • HY-154206
    N4-Benzo yl-5’-O-(4,4’-dimethoxytrityl)-aracytidine
    N4-Benzo yl-5’-O-(4,4’-dimethoxytrityl)-aracytidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    N4-Benzo yl-5’-O-(4,4’-dimethoxytrityl)-aracytidine
  • HY-154286
    1-O-Acetyl-2,3,5-tri-O-benzoyl-5(R)-C-methyl-D-ribo furanose
    1-O-Acetyl-2,3,5-tri-O-benzoyl-5(R)-C-methyl-D-ribo furanose is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    1-O-Acetyl-2,3,5-tri-O-benzoyl-5(R)-C-methyl-D-ribo furanose
  • HY-115736
    Xanthosine-5'-Triphosphate
    Xanthosine-5'-Triphosphate (5'-XTP), a nucleotide, is produced by deamination of purine bases. Xanthosine-5'-Triphosphate is a substrate of inosine triphosphate pyrophosphatase (ITPase).
    Xanthosine-5'-Triphosphate